Category: Genomics of Apicomplexa

Apr 24

Comparative genomic analysis and phylogenetic position of Theileria equi.

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Comparative genomic analysis and phylogenetic position of Theileria equi.
BMC Genomics. 2012;13:603
Authors: Kappmeyer LS, Thiagarajan M, Herndon DR, Ramsay JD, Caler E, Djikeng A, Gillespie JJ, Lau AO, Roa…

Apr 09

Genomics, population genetics and evolutionary history of Plasmodium vivax.

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Genomics, population genetics and evolutionary history of Plasmodium vivax.
Adv Parasitol. 2013;81:203-22
Authors: Carlton JM, Das A, Escalante AA
Abstract
Plasmodium vivax is part of a highl…

Jan 21

Comparative genome analysis of two Cryptosporidium parvum isolates with different host range.

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Comparative genome analysis of two Cryptosporidium parvum isolates with different host range.
Infect Genet Evol. 2012 Aug;12(6):1213-21
Authors: Widmer G, Lee Y, Hunt P, Martinelli A, Tolkoff M, Bodi K

Jan 21

Evidence of purifying selection on merozoite surface protein 8 (MSP8) and 10 (MSP10) in Plasmodium spp.

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Evidence of purifying selection on merozoite surface protein 8 (MSP8) and 10 (MSP10) in Plasmodium spp.
Infect Genet Evol. 2012 Jul;12(5):978-86
Authors: Pacheco MA, Elango AP, Rahman AA, Fisher D, Collins W…

Jan 21

Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity.

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Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13458-63

Authors: Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP

Abstract
Toxoplasma gondii is a highly successful protozoan parasite that infects all warm-blooded animals and causes severe disease in immunocompromised and immune-naïve humans. It has an unusual global population structure: In North America and Europe, isolated strains fall predominantly into four largely clonal lineages, but in South America there is great genetic diversity and the North American clonal lineages are rarely found. Genetic variation between Toxoplasma strains determines differences in virulence, modulation of host-signaling pathways, growth, dissemination, and disease severity in mice and likely in humans. Most studies on Toxoplasma genetic variation have focused on either a few loci in many strains or low-resolution genome analysis of three clonal lineages. We use whole-genome sequencing to identify a large number of SNPs between 10 Toxoplasma strains from Europe and North and South America. These were used to identify haplotype blocks (genomic regions) shared between strains and construct a Toxoplasma haplotype map. Additional SNP analysis of RNA-sequencing data of 26 Toxoplasma strains, representing global diversity, allowed us to construct a comprehensive genealogy for Toxoplasma gondii that incorporates sexual recombination. These data show that most current isolates are recent recombinants and cannot be easily grouped into a limited number of haplogroups. A complex picture emerges in which some genomic regions have not been recently exchanged between any strains, and others recently spread from one strain to many others.

PMID: 22847430 [PubMed – indexed for MEDLINE]

Jan 21

Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade.

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Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade.
Nat Genet. 2012 Sep;44(9):1051-5
Authors: Tachibana S, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto…

Jan 21

An evolutionary perspective on the kinome of malaria parasites.

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An evolutionary perspective on the kinome of malaria parasites.
Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2607-18
Authors: Talevich E, Tobin AB, Kannan N, Doerig C
Abstract
Ma…

Aug 18

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

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Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.
Nature. 2012 Jul 19;487(7407):375-9
Authors: Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O’Brien…

Jul 31

Genome sequences reveal divergence times of malaria parasite lineages.

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Genome sequences reveal divergence times of malaria parasite lineages.
Parasitology. 2011 Nov;138(13):1737-49
Authors: Silva JC, Egan A, Friedman R, Munro JB, Carlton JM, Hughes AL
Abstract
O…

Jul 31

Post-genomics resources and tools for studying apicomplexan metabolism.

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Post-genomics resources and tools for studying apicomplexan metabolism.
Trends Parasitol. 2011 Mar;27(3):131-40
Authors: Hung SS, Parkinson J
Abstract
The phylum Apicomplexa comprises over 50…