The Corradi Lab is currently seeking a Postdoctoral Fellow in the field of Fungal Comparative and Population Genomics. The research will be led by Dr. Nicolas Corradi and carried out in a CIFAR (Canadian Institute for Advanced Research) – affiliated laboratory located in the Department of Biology of the University of Ottawa, Canada. The …
Category: Uncategorized
Feb 11
Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa.
Gene-content evolution in discobid mitochondria deduced from the phylogenetic position and complete mitochondrial genome of Tsukubamonas globosa.
Genome Biol Evol. 2014 Jan 21;
Authors: Kamikawa R, Kolisko M, Nishimura Y, Ya…
Feb 09
Marine dinoflagellate proteomics: Current status and future perspectives.
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Marine dinoflagellate proteomics: Current status and future perspectives.
J Proteomics. 2014 Feb 3;
Authors: Wang DZ, Zhang H, Zhang Y, Zhang SF
Abstract
Dinoflagellates are not only the impor…
Feb 09
Applications of next-generation sequencing to unravelling the evolutionary history of algae.
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Applications of next-generation sequencing to unravelling the evolutionary history of algae.
Int J Syst Evol Microbiol. 2014 Feb;64(Pt 2):333-45
Authors: Kim KM, Park JH, Bhattacharya D, Yoon HS
Abstr…
Feb 04
W. Ford Doolittle wins Herzberg gold medal, top Science prize in Canada
We are thrilled to congratulate our colleague Ford Doolittle for this exceptional achievement. Ford is one of the pioneers in microbial evolutionary genetics, well known for his contributions to discover and understand the importance of lateral gene transfer (LGT or HGT) in evolution. Ford coined the expression “You are what you eat” to reflect that …
Jan 23
Horizontal gene transfer and redundancy of tryptophan biosynthetic enzymes in dinotoms.
Horizontal gene transfer and redundancy of tryptophan biosynthetic enzymes in dinotoms.
Genome Biol Evol. 2014 Jan 21;
Authors: Imanian B, Keeling PJ
Abstract
A tertiary endosymbiosis between a dinoflagellate…
Jan 23
Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.
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Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion.
Traffic. 2013 Aug;14(8):895-911
Authors: Frénal K, Tay CL, Mueller C, Bushell ES, Jia Y, Graindorge A, Billker O, Rayner JC, Soldati-Favre D
Abstract
The advent of techniques to study palmitoylation on a whole proteome scale has revealed that it is an important reversible modification that plays a role in regulating multiple biological processes. Palmitoylation can control the affinity of a protein for lipid membranes, which allows it to impact protein trafficking, stability, folding, signalling and interactions. The publication of the palmitome of the schizont stage of Plasmodium falciparum implicated a role for palmitoylation in host cell invasion, protein export and organelle biogenesis. However, nothing is known so far about the repertoire of protein S-acyl transferases (PATs) that catalyse this modification in Apicomplexa. We undertook a comprehensive analysis of the repertoire of Asp-His-His-Cys cysteine-rich domain (DHHC-CRD) PAT family in Toxoplasma gondii and Plasmodium berghei by assessing their localization and essentiality. Unlike functional redundancies reported in other eukaryotes, some apicomplexan-specific DHHCs are essential for parasite growth, and several are targeted to organelles unique to this phylum. Of particular interest is DHHC7, which localizes to rhoptry organelles in all parasites tested, including the major human pathogen P. falciparum. TgDHHC7 interferes with the localization of the rhoptry palmitoylated protein TgARO and affects the apical positioning of the rhoptry organelles. This PAT has a major impact on T. gondii host cell invasion, but not on the parasite’s ability to egress.
PMID: 23638681 [PubMed – indexed for MEDLINE]
Jan 22
Transcriptome de novo assembly sequencing and analysis of the toxic dinoflagellate Alexandrium catenella using the Illumina platform.
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Transcriptome de novo assembly sequencing and analysis of the toxic dinoflagellate Alexandrium catenella using the Illumina platform.
Gene. 2014 Jan 15;
Authors: Zhang S, Sui Z, Chang L, Kang K, Ma J, Kong F…
Jan 18
Genetic diversity of Cryptosporidium isolates from patients in North India.
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Genetic diversity of Cryptosporidium isolates from patients in North India.
Int J Infect Dis. 2013 Aug;17(8):e601-5
Authors: Sharma P, Sharma A, Sehgal R, Malla N, Khurana S
Abstract
BACKGROU…
Jan 10
Acyl-homoserine lactone quorum sensing in the roseobacter clade.
Acyl-homoserine lactone quorum sensing in the roseobacter clade.
Int J Mol Sci. 2014;15(1):654-69
Authors: Zan J, Liu Y, Fuqua C, Hill RT
Abstract
Members of the Roseobacter clade are ecologically important a…